HomeBiomarkersHeart Healthhs-CRP (High-Sensitivity CRP)
Cardiovascular

hs-CRP (High-Sensitivity CRP)

A sensitive measure of systemic inflammation — the process that turns stable plaque into heart attacks.

Optimal target< 1.0 mg/L (1.0–3.0 = average risk, > 3.0 = high risk)

What it measures

High-sensitivity C-reactive protein (hs-CRP) is a precise measure of C-reactive protein, a protein produced by the liver in response to inflammation. The high-sensitivity assay detects the low-grade, chronic inflammation that damages blood vessels and destabilizes atherosclerotic plaque.

Elevated hs-CRP is associated with increased cardiovascular risk because inflammation is what transforms stable plaque into ruptured plaque — the event that causes most heart attacks.

Why it matters

  • Measures the chronic, low-grade inflammation that drives atherosclerosis.
  • Elevated hs-CRP predicts cardiovascular events independent of cholesterol.
  • Flags the process that destabilizes plaque and causes heart attacks.
  • Responds to lifestyle changes — a useful progress marker.

What affects your levels

Chronic stress and poor sleep
Visceral fat and metabolic syndrome
Poor diet (ultra-processed foods, sugar)
Sedentary lifestyle
Acute illness or injury (transiently raises hs-CRP — retest when well)

How VitalDrop tracks it

  • Monthly trends distinguish chronic inflammation from a temporary spike.
  • Paired with lipids for a complete cardiovascular risk profile.
  • Tracks whether anti-inflammatory lifestyle changes are working.

Related biomarkers

Frequently asked questions

Yes. hs-CRP rises acutely with any infection, injury, or inflammation. A single elevated reading during or shortly after an illness doesn't reflect your baseline. This is exactly why monthly trend tracking is valuable — it distinguishes a temporary spike from chronically elevated inflammation.

References & sources

01.
High-Sensitivity CRP and Cardiovascular Risk Prediction. New England Journal of Medicine, 2019.Source
02.
Inflammation and Atherosclerosis. Circulation, 2020.
Medically reviewed by
DH
Reviewed by Dr. Hassan Nasser
Medical Director — www.detroitfacemd.com

Board-certified facial plastic & reconstructive surgeon; clinical reviewer for VitalDrop laboratory insights. Verified at www.detroitfacemd.com

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Medical disclaimer: This content is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. VitalDrop provides laboratory test results and educational insights for wellness tracking. Always consult a qualified healthcare provider regarding abnormal or concerning results. Results and AI-assisted summaries are not a medical diagnosis.